Skin in balance: Joint forces of polarity and cell mechanics

The cell polarity protein Par3 controls mechanical changes in the skin and plays an important role in cell division. Malfunction can lead to DNA damages. The balance of the system is of great importance—while too much differentiation leads to loss of stem cells and therefore premature aging, too many cell divisions can be a cause of skin cancer. The new study by a team around Sandra Iden about how polarity regulators control cellular mechanics in the skin has now been published in Nature Communications.

source https://www.lifetechnology.com/blogs/life-technology-news-blog/skin-in-balance-joint-forces-of-polarity-and-cell-mechanics