Nerve cell protection free from side effects

The hormone erythropoietin (Epo) is a well-known doping substance that has a long history of abuse in endurance sports such as cycling. In addition to promoting red blood cell production (erythropoiesis), which improves the oxygen supply, Epo also protects nerve cells from cell death. In order to use this effect to cure neurodegenerative diseases, however, the negative effects caused by Epo through the stimulated formation of red blood cells need to be prevented. Researchers at the University of Göttingen have now discovered an alternative Epo receptor that could potentially also trigger protective effects in humans without the side effects on erythropoiesis. The results were published in the journal Frontiers in Molecular Neuroscience.